Fakhar Zaman fashioned an attacking 66 before Khyber Pakhtunkhwa's bowlers produced a fine performance as Central Punjab crashed to their fourth consecutive defeat.
Fakhar's brilliant half-century was supplemented with a number of useful contributions from the rest of the batsmen to take KP to a daunting total of 178-7.
The belligerent left-handed batsman got going immediately in the Powerplay, taking full use of the fielding restrictions to frequently find the boundary fence.
Fakhar reached the 50-run mark in style with a couple of towering maximums off Bilal Asif's bowling to signal his aggressive intent.
He was finally dismissed in the 14th over with Zafar Gohar getting the better of him as he consumed 42 balls for his valiant knock.
Having raced to 142-4 in 15 overs, KP stuttered in the final quarter of their innings and failed to respond with a late flourish.
Shoaib Malik struggled for fluency throughout his unbeaten 27, hitting only three boundaries at a strike rate of 112.50.
Right-arm paceman Ahmed Bashir was the pick of the bowlers for Central Punjab as he took three wickets in his four-over spell.
CP's chase seemed to be thriving smoothly with Abdullah Shafique and Kamran Akmal sharing a 92-run stand for the second wicket in quick time.
The progress made by them was undone by regular breakthroughs, which hauled KP back into a dominant position in the match.
Akmal was the first to go in the dramatic slide that culminated in Central Punjab's demise when he was strangled down the leg-side in Malik's solitary over.
Shafique, the current leading run-getter in the competition, was dismissed by Arshad Iqbal for 43. His departure was followed by a lack of defiance from the lower-order since they were unable to meet the asking rate.
Iftikhar Ahmed cleaned up the stumps of CP skipper Saad Nasim in the last over to register another comfortable victory for KP.
Central Punjab continue to languish at number five in the points table but they will be buoyed by the inclusion of Babar Azam for the Rawalpindi leg of the tournament.