Cricket Australia said Thursday that players picked in Australia's World Cup squad won't be allowed to take part in the final few weeks of the Indian Premier League.
The IPL runs from late March till mid-May with the World Cup in England and Wales starting on May 30.
After a tough run this year, Cricket Australia are determined the players' key focus is on defending their one-day title ahead of an Ashes series against England.
The guidelines suggest that anyone selected in the 15-player World Cup squad must attend a pre-tournament camp in early May.
Players who will require an approval from CA to feature in the IPL, must also complete their Sheffield Shield duties before leaving for the tournament.
Cricket Australia's interim Team Performance chief Belinda Clark said the rules were "in the interest of making Australians proud of our team".
"We are working hard to ensure their health and match readiness ahead of what will undoubtedly be a huge year in cricket, while respecting the players’ interests in playing in the various formats," she said.
"It is a difficult period with the IPL being brought forward to accommodate the Cricket World Cup, and overlapping our domestic season.
The 2019 IPL auction is due to take place next month with Australian players often bagged on lucrative contracts.
As Australian cricket has gone through a tough year after an infamous ball-tampering scandal in March this year, several former greats, led by Shane Warne, have called for a return to basics.
That involves more game time for top players in the Sheffield Shield and less focus on shorter version.
Clark, a former captain of the Australian women's team, said the IPL decision was "a reasonable balance that will enable the players to consider their options and choose what is right for them and their respective teams".
"It is imperative that we ensure Australia is in the best possible position as we head into the Cricket World Cup and the 2019 Ashes series," she added.