Speedster Chris Morris claimed two key wickets as South Africa strangled Australia to a 21-run victory in their rain-reduced Twenty20 international on the Gold Coast on Saturday.
The South Africans easily protected their 108 for six total off 10 overs to restrict Australia to 87 for seven with Morris the star of the Proteas bowling attack.
Morris claimed the wickets of D'Arcy Short for a first-ball duck and Chris Lynn for 14 in his opening over to trigger a wicket slide.
The Australians fell away from 21 for one after two overs to be 60 for six upon the dismissal of Alex Carey for eight in the seventh over with Lungi Ngidi (2-16) and Andile Phehlukwayo (2-21) also among the wickets.
"The bowlers once again stepped up and produced the goods. Picking up wickets in this format is always important because T20 is all about slogging," skipper Faf du Plessis said.
"It ends a really good tour for us. We learnt a few lessons about the things that worked and didn't work.
"Australia is a very tough place to tour and play cricket in, so to get a series win in both white-ball formats is a big achievement and we'll go home with our heads held high."
South Africa also downed Australia 2-1 in the one-day series preceding the one-off T20 international.
Glenn Maxwell was Australia's topscorer with 38 off 23 balls with two sixes but was guilty of moving around the wicket and missing hittable deliveries as the pressure mounted on the home side.
"I think they (South Africa) got off to a great start with the bat. We did well to pull it back in the end, but they had a lot of runs with them," Australia captain Aaron Finch said.
"The boys are hurting as much as anyone but we'll turn it around real quick (in the home series) against India."
In the end the difference was the execution of the powerplays. South Africa smashed 42 runs, losing just the one wicket, while Australia could manage only 27, and lost their top three batsmen.
Earlier Andrew Tye and Nathan Coulter-Nile claimed two wickets each as South Africa reached 108 for six after being sent into bat.
The Proteas got away to a flyer with opener Quinton de Kock clubbing 22 off 16 balls with two sixes and du Plessis hitting 27 from 15 balls.
The South Africans raced to 42 inside the opening three overs before Coulter-Nile claimed the wicket of Reeza Hendricks for 19 caught in the deep by Ben McDermott.
Maxwell had de Kock stumped by wicketkeeper Carey and two overs later du Plessis fell to a brilliant leaping catch over the boundary rope by Maxwell off Billy Stanlake.
That left South Africa at 84 for three, triggering a rash of late wickets for only 24 runs.
Heinrich Klaasen chipped in with 12 and David Miller hit 11, before he was the first of Tye's wicket double.
Tye bowled out his only two overs at the end of the innings to finish with two for 18 while Coulter-Mile captured two for 19.
The match was reduced to 10 overs a side after heavy rain prevented a scheduled start.
The T20 is the start of four matches for Australia over the next week with three internationals against India.