Fresh from a stunning 2-1 triumph in the Test series, Jason Holder leads a Caribbean team which is still finding its feet in the 50-over format and is hampered by the absence of key players for a variety of reasons.
In contrast, Eoin Morgan's side have vaulted to the top of the world rankings and a comfortable 171-run victory in their lone warm-up fixture on Sunday suggests that they will not be hampered by the challenges encountered by the Test team.
Opening batsman Jason Roy and Test skipper Joe Root both stroked fluent hundreds in a total of 371 for seven, while all the bowlers used enjoyed a measure of success against the West Indies Vice-Chancellor's XI with opening bowlers Mark Wood and Chris Woakes, together with leg-spinner Adil Rashid, taking two wickets each.
While the memory of a 381-run thrashing in the first match of the three-Test series less than a month ago is fresh, England's last ODI at Kensington Oval two years ago was a 186-run thrashing which completed a 3-0 sweep of West Indies.
The results for West Indies have not improved significantly since that humbling, with the former champions missing out on the 2017 Champions Trophy and scraping through last year's qualifying tournament in Zimbabwe to advance to the World Cup in England and Wales, which starts on May 30 in England this year.
Already without mystery spinner Sunil Narine and all-rounder Andre Russell, West Indies had to amend their original squad for the first two ODIs with injuries ruling out opening batsman Evin Lewis and all-rounders Rovman Powell and Keemo Paul.
John Campbell, who made a decent start to his Test career in the three matches against England, looks set for an ODI debut opening the batting with Chris Gayle.
On Sunday, Chris Gayle revealed that the World Cup 2019 will be his farewell to the format.
"Yes I'm looking to draw the line after the World Cup," said the big-hitting left-hander and former captain.
"I'll let the youngsters have some fun and I can sit back in the party stand and watch them have some fun. Winning the World Cup would be a fairytale finish."
Jason Holder (captain), Chris Gayle, John Campbell, Darren Bravo, Shai Hope (wicketkeeper), Shimron Hetmyer, Carlos Brathwaite, Ashley Nurse, Kemar Roach, Sheldon Cottrell, Oshane Thomas
Eoin Morgan (captain), Jason Roy, Alex Hales, Jonny Bairstow (wicketkeeper), Joe Root, Ben Stokes, Moeen Ali, Chris Woakes, Liam Plunkett, Adil Rashid, Mark Wood