Hardik Pandya will miss the upcoming limited-overs series against Australia due to lower back stiffness, BCCI said in a statement.
India will field a 14-man squad instead of the original 15 for the two T20 matches starting Sunday in Visakhapatnam.
Ravindra Jadeja will replace Pandya for the five one-day internationals that follow the T20s.
"The BCCI medical team decided to rest the all-rounder and let him undergo strength and conditioning work for his lower back at the National Cricket Academy in Bengaluru," it said.
"Mr. Pandya will begin his strength work from next week."
Pandya is expected to hold the key to India's chances at the World Cup starting May 30 in England and Wales.
The 25-year-old recently found himself in trouble for making sexist comments on a TV chat show.
Pandya bragged about his encounters with multiple women on the programme in January with teammate K. L. Rahul sitting next to him.
Pandya has scored 731 runs from 45 ODIs at an average of nearly 30, and has 44 ODI wickets.