Fast bowlers Lungi Ngidi and uncapped Anrich Nortje were included in a 14-man South African squad for the first three of five one-day internationals against Sri Lanka.
Veteran batsman Hashim Amla was not included for the start of South Africa's last series before the Cricket World Cup in England from May to July.
"Those players who were in the squad against Pakistan (in January) but who have been left out this time have not been dropped. We need to use the first part of this series to examine all the options that are available to us," said selection convener Linda Zondi. "We know, for example, what Hashim Amla has to offer us and he remains a senior member of our squad."
Another notable exclusion from the squad is of JP Duminy, who has not played since October because of a shoulder injury. Zondi said he hoped that Duminy, regarded as a key to South Africa's World Cup hopes because of his all-round abilities would be fit for the final two matches against Sri Lanka.
Ngidi and Nortje, who made a sensational impression with his pace in a T20 tournament early in the season, have both returned to action in recent weeks. Ngidi suffered a knee injury during the Australia tour in November, while Nortje has been sidelined by an ankle problem.
Faf du Plessis (captain), Quinton de Kock (wkt), Reeza Hendricks, Imran Tahir, David Miller, Wiaan Mulder, Lungi Ngidi, Anrich Nortje, Andile Phehlukwayo, Dwaine Pretorius, Kagiso Rabada, Tabraiz Shamsi, Dale Steyn, Rassie van der Dussen