His replacement Mohammed last played a game for the West Indies way back in July last year against Bangladesh.
The 32-year-old, who has captained his national side in the past as well, has been rewarded for a productive first-class season with Trinidad & Tobago.
"We welcome Jason Mohammed into the squad for the first two T20 matches here in Florida. He is a player with lots of experience in all three formats," interim head coach Floyd Reifer said.
"It is not easy to fill the shoes of someone like Andre Russell, who has dominated T20 cricket all over the world and helped West Indies win the ICC T20 World Cup on two occasions.
"We believe Jason is capable of good performances and we back him to perform at this level and win games as well."
The two teams will then travel to Guyana to participate in the final match of the series.
The T20 contests will be followed by three ODIs and two Tests that count towards the calculation of the recently inaugurated World Test Championship.