Jason Roy and Craig Overton have been dropped for the fifth and final Test at the Oval, it was announced on Wednesday. Sam Curran and Chris Woakes have been inducted into the side.
Sam Curran has been included as fourth seamer, covering in for Ben Stokes who injured his shoulder and will play as a specialist batsman.
Roy has had a torrid time in the Ashes so far, scoring 110 runs at an average of 13.75.
England captain Joe Root said: "It's always tough to leave guys out but Stokesy picked up a shoulder injury in the last game.
"He won't be able to bowl the overs you'd normally expect him to and I think it would be a risk to take him into the game as a fourth seamer.
"He might be able to bowl a couple of overs here and there but his batting is, as this series has shown, a massive part of this side and he rightly deserves to be in the team as a top-four batter.
Root said Roy couldn’t quite kick on in Test cricket but he was confident that he [Roy] would come back hard.
"Jason has had an opportunity to come in and play Test cricket and get a feel for it and it has not quite gone as he would have liked, but I'm sure he'll go away and work extremely hard and come back again.
"That's what you expect of guys when they get left out. I'm sure he'll have that attitude. He'll want to prove a point and get himself back into the side.”
Joe Root (c), Jofra Archer, Jonny Bairstow (wk), Stuart Broad, Rory Burns, Jos Buttler, Sam Curran, Joe Denly, Jack Leach, Ben Stokes, Chris Woakes.