Duminy's blistering 20-ball 65, adorned by four boundaries and seven maximums, lifted his side's total to a daunting 192-5.
The Tridents' batting charge was followed by Hayden Walsh's maiden five-wicket haul in T20I cricket as Trinbago were bundled out for 129 in 17.4 overs.
The platform for an imposing Tridents total was earlier set up by a 110-run opening partnership between Jonathan Carter and Johnson Charles.
The quick dismissals of the two openers did little to hamper the home side's brisk progress with Duminy opting for the aerial route and achieving great levels of success.
The left-handed batsman, who called time on his career following the World Cup in England and Wales, reached three runs in five deliveries before launching six sixes in his next ten balls.
Duminy raced to 50 in just 15 balls - a CPL record - and fell in the final over of the innings having plundered the opposition bowling attack to all parts of the ground.
The Knight Riders chase began sprightly as they muscled to 67-2 by the end of the Powerplay.
The initial impetus was short-lived in the face of USA spinner Walsh's incredible spell of 5-19 in four overs.
Kieron Pollard was dismissed for just three while Jimmy Neesham fell to Walsh for a golden duck leaving Trinbago in a state of total chaos.
Duminy employed his part-time off-spin towards the end of the innings to fittingly claim the last wicket of the match and help Barbados register their third win of the season.
“Don't how to put that into words, it's an unbelievable spectacle, the CPL,” Duminy said after being declared player of the match.
“In my opinion, Hayden Walsh was the Man of the Match. To see catches being taken, and watching guys partying on the field, was awesome.”