David Warner etched his name in the history books with the second-highest Test score by an Australian before Mitchell Starc ripped out Pakistan's middle-order under the Adelaide Oval lights to leave the tourists in tatters at 96 for six.
Warner feasted on the Pakistan bowlers' erratic lines to smash an unbeaten 335 on a day where records tumbled.
Skipper Tim Paine's decision to call back the Australia batters with the score reading a colossal 589-3 meant Warner walked off the field having registered the 10th highest Test score.
The declaration opted almost half an hour before the dinner break deprived Warner of a potential chance to break Brian Lara's all-time high 400 not out.
The Aussie quicks then rattled Pakistan's hapless batsmen turning an already miserable time for their opponents worse as the latter look set to concede a gargantuan lead.
Pakistan lost four wickets to a cracking spell of pace bowling from Starc as the humiliation mounted for the visitors.
Babar Azam was the sole respite for Pakistan on a pitch deemed flat when Warner was in the midst of his immaculate batting display.
Azam was not out at 43 as he frequently found himself stranded on the other end with batting partners departing in succession leaving little time for a partnership to rescue Pakistan.
Starc and company - Josh Hazlewood and Pat Cummins - had already exposed Pakistan's long tail with veteran spinner Nathan Lyon yet to be introduced into the attack.
The notion of success completely evaded Azhar Ali's men, who were blown away by Warner's voracious appetite to pile on runs effortlessly.
Pakistan entered the day-night Test match having lost 13 consecutive five-day games in Australia but their embarrassing streak is likely to be extended in the face of merciless pounding from the hosts.
Shaheen Afridi briefly celebrated the wickets of Marnus Labuschagne (162) and Steve Smith (36) in the first session but that was the last bit of relief for Pakistan.
Labuschagne and Warner had begun the day at a canter, punishing spinners Iftikhar Ahmed and Yasir as the latter leaked runs at a rate of 6.15 per over.
Their marathon 361-run stand for the second wicket is now a record for Australia against Pakistan.
Meanwhile, Warner had another stroke of luck when he was caught at gully off the bowling of debutant Muhammad Musa, which was called a front-foot no-ball by the umpire.
Musa now joins the unwanted list of cricketers to have dismissed Warner off a no-ball in their maiden appearance in Test cricket - Tom Curran and teammate Naseem Shah being the other two bowlers.
Warner then made them pay heavily by surpassing his previous-best score of 253 before motoring along to hammer a flick through midwicket off Mohammad Abbas to become the seventh Australian to hit a triple hundred.
The jubilant southpaw then poured out his emotions in an animated celebration that brought tears to his wife's eyes, who was seated in the stands witnessing the historic moment.
Paine finally decided it was time for his bowlers to build on Warner's stellar knock and asked the Pakistani batters to tackle the pink ball under lights.
Imam-ul-Haq, drafted into the side in place of the struggling Haris Sohail, was the first person to be dismissed and Azhar soon followed, having demoted himself to the No. 3 position in the batting order.
Earlier, Smith created the record for the fastest to 7,000 Test runs as he also went past Donald Bradman's tally of 6,996 runs.