Opening batsman Dom Sibley has become the 11th England player to suffer an illness amidst the ongoing tour of South Africa.
Sibley, who made his debut against New Zealand a month ago, was involved in a gritty opening stand with Rory Burns in the second innings of the first Test at Centurion before being dismissed for a 90-ball 29.
As England crashed to a 107-run defeat on the fourth day of the series opener, skipper Joe Root refused to offer the unusual bout of illnesses in the England camp as an excuse for his side's underwhelming performance.
"It's been a tough week off the field, pretty much everything has been thrown at the group. Hopefully, we can bounce back strongly," he said on Sunday.
Ollie Pope, Chris Woakes and Jack Leach were unavailable for the first match but are now out of quarantine.
Root, Jos Buttler and Ben Stokes were also forced to spend time off the field during the game whereas Stuart Broad and Jofra Archer had earlier missed the warm-up games.
In addition to the 11 members of the touring party, six people from the support staff have succumbed to different viral illnesses as well.
While this development adversely affects England's preparations, the visitors will travel to Cape Town with the whole squad intact for the next game that commences on January 3.