David Warner and Aaron Finch hammered the South African bowlers to ensure a dominant 97-run victory in the series-deciding third T20I at Newlands.
Proteas skipper Quinton de Kock's decision to bowl first backfired as Australia piled on misery on the home side.
Warner and Finch compiled half-centuries in a feisty opening stand as Australia reached an imposing total of 193 for five in their 20 overs.
South Africa were then shot out for just 96 on the board, just seven runs more than their record-lowest total, which came against the same opposition in Johannesburg last week.
Mitchell Starc broke the back of South Africa's chase by prising out the important scalp of de Kock in the first over of the innings.
He then followed it up with the dismissal of Faf du Plessis and finished with a tally of three wickets, earning him the man of the match prize.
Meanwhile, Finch took home the player of the series award and was elated by his team's effort to recoup their confidence from the loss in the second T20I to inflict damage on South Africa.
"The guys have bought into the roles they have been asked to play," he said.
Finch singled out aggressive running between the wickets and heralded it as something they "pride" themselves on.
On the other hand, South Africa's series-losing streak has stretched to over a year with de Kock reiterating the need for keeping their spirits high in the forthcoming assignments.
"It's quite disappointing the way we lost," said De Kock. "We have to keep our heads up and keep looking forward."
The six-over Powerplay proved to be the difference between the two teams with Australia waltzing their way to 75 without loss while South Africa were 50-2 by this mark of the innings.
The hosts then suffered a massive collapse in the second half, losing their last five wickets for just nine runs as Ashton Agar came close to grabbing his second hat-trick in three games.
The magical feat, however, evaded him as the batsman was able to play out the hat-trick delivery.
He shared five wickets with fellow spinner Adam Zampa, helping Australia steamroll the opposition inside 15.3 overs.