Shaheen Afridi spearheaded Khyber Pakhtunkhwa's dominant performance with a destructive spell of bowling that accounted for five Sindh batsmen.
After restricting Sindh to a modestly competitive total of 183-7, KP cruised to the target at the expense of two wickets and an over to spare.
The highlight of the day belonged to Shaheen, who kick-started his reign of terror with an unplayable yorker to remove Khurram Manzoor in the second over of the innings.
The veteran opening batsman had feasted on Mohammad Hafeez's lacklustre bowling in the first over but was beaten by a rapid full-length delivery that ripped out the off pole.
To further stamp his authority on the proceedings, Shaheen got the wicket of the in-form Azam Khan as the batter was deceived into chipping a slower delivery straight to the fielder at mid-off.
Shaheen's marvellous start was neutralised by aggressive strokeplay from Sharjeel Khan, who did not shy away from taking the aerial route and depositing the ball beyond the fences.
Sharjeel and Ahsan Ali were involved in a 111-run stand with the bulky left-handed opening batsman bullying the bowlers with his intimidating shots as he blasted 90 off 56 deliveries.
After motoring along unperturbed, Sharjeel met his match in Shaheen with the paceman rattling his stumps in the 18th over.
Shaheen added two more to the wickets column including another well-directed yorker to vanquish Sohail Khan.
Shaheen finished with astounding figures of five for 21, his third five-wicket haul in five matches and the second-most (4) for any bowler in T20 cricket.
KP's chase was disrupted in the beginning owing to the loss of skipper Mohammad Rizwan but Fakhar Zaman and Hafeez steadied the ship with an array of scintillating strokes.
Fakhar's carnage was dwarfed by a blistering knock from Hafeez, who plundered four sixes in his unbeaten 42-ball 72.
Fakhar also reached his half-century in KP's successful chase and was later removed by Anwar Ali, allowing Iftikhar Ahmed to come in and hammer the final nail in the coffin for Sindh.
Iftikhar struck three towering maximums in his swift contribution of 40 runs as KP claimed their third win on the trot.