Shadab Khan will miss Pakistan's first ODI in 12 months after enduring stiffness in his left upper-leg during one of the intra-squad practice games before the series against Zimbabwe.
Pakistan are all set to lock horns with Zimbabwe in the first of the three ODIs on Friday in Rawalpindi but they will be without the services of ace all-rounder Shadab.
Pakistan last played a 50-contest over a year ago against the touring Sri Lankan side in Karachi, managing to defeat them by five wickets.
Shadab was recently appointed Pakistan's new white-ball vice-captain, assisting skipper Babar Azam. His absence from the opening Zimbabwe game might pave the way for leg-spinner Usman Qadir's international debut or slow left-arm orthodox Zafar Gohar's first ODI in five years.
Shadab was in action in the National T20 Cup for semi-finalists Northern and excelled with both bat and ball. He also captained his team before the arrival of Imad Wasim from the T20 Blast and led Northern through an unbeaten run during the Multan leg of the competition.
"Shadab will continue to be treated and rehabilitation regime and a further update will be provided ahead of the second ODI," the PCB added in its press release.
Pakistan engaged in two warm-up matches in Lahore before moving to Rawalpindi for the three ODIs and as many T20Is.