Pakistan will have three away series and two home assignments in the ICC World Cup Super League in 2021.
The home series will take place against New Zealand and West Indies in October and December next year, respectively.
Although details of the two teams' prospective trips are to be confirmed in the future, top-flight international cricket has been gradually returning to Pakistan.
West Indies last toured Pakistan in 2018 for a short three-match T20I series in Karachi whereas New Zealand's cricket team has not visited the country since 2003.
The New Zealand series will be a return trip as Pakistan's squad will embark on a tour of the island nation later this month to play three T20Is and two Test matches.
The ODI contests against the Black Caps are expected to be held before England's T20I series in Pakistan, which serves as a lead-up to the T20 World Cup in India.
The other ODI Super League fixtures confirmed by the Pakistan Cricket Board (PCB) are the away series against South Africa (April 2021), England (July 2021) and Afghanistan (September 2021).
The 50-over meetings between Pakistan and Afghanistan will mark the first bilateral series amongst the two neighbouring rivals.
Pakistan's tour of England will also consist of three T20Is in addition to as many ODIs. All the matches will be staged in different venues with the ODIs to be played in Cardiff, London and Birmingham while the T20Is will be held in Nottingham, Leeds and Manchester.
The World Cup Super League adds context to the plethora of bilateral series existing in the international cricket calendar. At the moment, Pakistan occupy the second spot on the 13-team table following their 2-1 win over Zimbabwe at home.
Top seven teams and hosts India will earn direct qualification to the ICC World Cup 2023 with the rest of the teams set to take part in the Qualifiers to slot in the remaining two spots.
Reflecting on Pakistan's tour of England next summer, captain Babar Azam said: “England and Wales is our second home as we have been visiting it regularly since 2016. Apart from building relationships and understanding the culture, these tours have helped us to enhance and improve our cricket skills and knowledge, as we now have a good understanding of the conditions and wickets in that part of the world."
“England are the world champions and the number-one ranked side in ODIs, while they sit second in the T20I table. Besides trying to collecting valuable Super League points, our overarching objective is also to improve our white-ball rankings.
"The series against South Africa, England and New Zealand provides us with opportunities to improve our rankings as lower-ranked sides are awarded more points if they win a series against the side that is ranked above them on the rankings table."