Southern Punjab captain Sohaib Maqsood won the toss and asked Sindh to bat first, opener Sharjeel Khan (44 off 38, three fours, three sixes) provided the side a flying start after the early loss of Khurram Manzoor (1).
Captain Saud Shakeel and Asad Shafiq added 66 runs for the third-wicket before Asad fell to Aaron Summers for 45 (46 balls, five fours).
Wicketkeeper batsman than upped the scoring rate for Sindh with a whirlwind 69 off 36 balls, the right-hander hit eight fours and three sixes. Saud fell for 60 off 78 balls (three fours), Hassan Khan scored an unbeaten 38 off 28 balls to take his side past the 300-run mark, Sindh were bowled out for 309 in 49.1 overs. Pacers Mohammad Ilyas and Summers took three wickets each.
Salman (player-of-the-match), who was one of the leading scorers in the recently concluded Quaid-e-Azam Trophy, continued his rich vein of form by scoring a sparking unbeaten 106 off 75 balls that took Southern Punjab home.
The right-hander, who came into bat at number five in the batting order, hit nine fours and three sixes in his innings.
Opener Zain Abbas who had retired hurt came back to finish the chase with Salman, he remained unbeaten on 75 off 79 balls (nine fours).
Sohaib contributed 36 off 28 balls (three fours, two sixes). Southern Punjab chased down the target for the loss of six wickets in 48.3 overs.
Anwar Ali and M0hammad Umar took two wickets each for Sindh.