New Zealand remain 1-0 up in the series with the third and final match at Mount Maunganui on Wednesday.
Debutant Seth Rance sparked a West Indies batting meltdown as New Zealand cruised to a 47-run victory in the opening Twenty20.
It is the second change for the tourists, who have already had to replace the injured Ronsford Beaton
Fast bowlers Trent Boult and Matt Henry along with spinner Mitchell Santner took the batting apart.
Boult took seven for 34 as the West Indies folded at Hagley Oval for 121 in reply to New Zealand's substantial 325 for six.
The tourists reached 248-9 after losing the toss and being sent in to bat, a target the Black Caps overhauled with four overs remaining.
Zimbabwe-born de Grandhomme was travelling to Harare to be with his family and will be replaced in the squad by Doug Bracewell.
A brutal spell from Wagner produced three wickets and a broken arm as the hosts romped to a 240-run victory
The West Indian captain was found guilty of maintaining a slow over rate.
LPL draft: 8 Pakistan players picked, Gayle joins Kandy, Russell goes to Colombo
Abdullah Shafique gets maiden call-up; Sarfaraz Ahmed, Shoaib Malik dropped for Zimbabwe series
Southern Punjab call up Dilbar Hussain; Balochistan drop Imran Farhat for Rawalpindi leg
National T20 Cup: Three-way race to the last semi-final spot
PCB presents financial draft proposal to PSL franchise owners
Misbah-ul-Haq quits as Pakistan chief selector, will continue as head coach
Umar Gul calls time on his professional career
Lanka Premier League player draft delayed once again
PCB issues warning after nine players and three officials violate Covid-19 protocols
Quaid-e-Azam Trophy: Hasan Ali, Ahmed Shehzad return, Yasir Shah named Balochistan captain