New Zealand remain 1-0 up in the series with the third and final match at Mount Maunganui on Wednesday.
Debutant Seth Rance sparked a West Indies batting meltdown as New Zealand cruised to a 47-run victory in the opening Twenty20.
It is the second change for the tourists, who have already had to replace the injured Ronsford Beaton
Fast bowlers Trent Boult and Matt Henry along with spinner Mitchell Santner took the batting apart.
Boult took seven for 34 as the West Indies folded at Hagley Oval for 121 in reply to New Zealand's substantial 325 for six.
The tourists reached 248-9 after losing the toss and being sent in to bat, a target the Black Caps overhauled with four overs remaining.
Zimbabwe-born de Grandhomme was travelling to Harare to be with his family and will be replaced in the squad by Doug Bracewell.
A brutal spell from Wagner produced three wickets and a broken arm as the hosts romped to a 240-run victory
The West Indian captain was found guilty of maintaining a slow over rate.
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