Babar Azam (90) and Hussain Talat's (55) knocks went in vain as Pakistan collapsed from 147-1 to 181-7 courtesy Phehlukwayo and Morris' bowling
South Africa prevailed by six runs in a tense finish after being sent in and making 192 for six.
De Kock slammed 83 off 58 balls as South Africa chased down a target of 241 with seven wickets and ten overs to spare to seal a 3-2 series win.
"Whatever happened has happened," Sarfraz told media at the airport after landing from Cape Town.
This is also the first time ever Pakistan won an ODI against South Africa at the Wanderers
Shoaib Malik will lead Pakistan in the remaining two ODIs and the subsequent T20I series against South Africa
The Pakistan captain later apologised for the comment on Twitter.
Pakistan will play a three-match T20 series against South Africa after the completion of undergoing five-match ODI series
Imam's 101 spurred Pakistan to an imposing 317 for six but South Africa won by 13 runs according to the Duckworth/Lewis/Stern method
PCB plan to hold pre-England tour camp from early June under ‘strict bio-secure environment’
Afridi buys Mushfiqur's bat to raise funds for virus affectees in Bangladesh
England tour could get green signal as PCB and ECB hold positive talks: reports
3 players who may have played their last PSL
Pakistan's tour to Ireland for two T20Is postponed
ICC publishes guidelines for safe resumption of cricket
Babar Azam confirmed as Pakistan's new ODI skipper
Faheem Ashraf, Kieron Pollard's Northamptonshire contracts cancelled
'Keeping fingers crossed' - Babar Azam hoping for T20 World Cup to get underway
Taufeeq Umar self-isolates after testing positive for coronavirus