Du Plessis lamented the loss of off-spinner Simon Harmer, who signed a Kolpak contract in 2016 and has not appeared for South Africa since then.
The Proteas could manage to add only a single run to their overnight total before Nadeem secured the last two wickets in successive balls.
South Africa were 132-8 at the close of play with India requiring two wickets to wrap up a series sweep over Faf du Plessis' men.
"Those catches, they stick or they don't. So unfortunately it wasn't our way, it was Rohit's. He played well, so well done to him."
South Africa were in trouble at nine for two, with Indian fast bowlers sending the opposition openers back to the pavilion in Ranchi.
"If he starts coming good top of the order, it changes everything for the Indian team, even when you're touring."
Sharma, on 117, combined with Ajinkya Rahane, on 83, to put on an unbeaten 185-run stand after the hosts were wobbling at 39-3.
South Africa seek to turn the tables on India and get a consolatory win to bag crucial Test championship points after losing the Test series
Aiden Markram will not be available for the third and final Test against India after he sustained a wrist injury during the previous game in Pune.
3 players who may have played their last PSL
Haider Ali talks about his comparison with Babar Azam and Virat Kohli
5 reasons why Pakistan lost semifinal against India in ICC WorldCup 2011
Pakistan players allowed to take part in four leagues including PSL
Pakistan rule the charts for successful DRS use
3 possible windows for PCB to resume remaining HBL PSL V
Babar Azam’s tribute to medical staff
PCB turns high performance center into living facility for paramedics
Sammy gives important message on Pakistan Day
Islamabad United donates 1 million to lockdown fund